Prof Jon Arch

The Clore Laboratory
University of Buckingham
Hunter Street
Buckingham
MK18 1EG
Tel: +44 (0)1280 820306

Biography

Jon was the Deputy Director of Metabolic Research for the Clore Laboratory from 2001 to 2014. He became the Dean of Science (later Dean of Science and Medicine) in January 2011. He retired from these roles in June 2014, but continues to support the research of the Clore Laboratory. He has been a personal tutor for medical students since the undergraduate medical course began in January 2015. He was awarded the title and privileges of ‘Emeritus Professor’ in the University in March 2016.

Prior to moving to Buckingham, Jon worked in drug discovery in the pharmaceutical industry. He maintained a connection with the pharmaceutical industry through various consultancies and membership of scientific advisory boards. He has also been a governor (director) of a nutrition institute and a member of scientific advisory panels for two European Union research consortia.

Research

Jon’s long-standing interest has been in the regulation of energy expenditure in relation to the cause and treatment of obesity and type 2 diabetes. He has also published on the regulation of energy intake by the central nervous system, and other aspects of the regulation of energy balance and insulin sensitivity. Whilst most of his career has focused in metabolic disease, he spent six years working on novel bronchodilators for asthma.

Publications

A full list of Jon’s publications can be found on Google Scholar.

As of April 2019, Jon has an h index of 58 (28 since 2014), which is the number of his publications that have been cited at least that number of times.

Some of his most cited or more recent publications are:

Ben Khedher MR, Hammami M, Arch JRS, Hislop DC, Eze D, Wargent ET, Kępczyńska MA, Zaibi MS.PeerJ. (2018)  Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone. Jan 6:e4166. DOI: 10.7717/peerj.4166

.Yavari A, Stocker CJ, Ghaffari S, Wargent ET2…. Arch JR, Cawthorne MA, Watkins H, Ashrafian H (2016) Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metab. 23:821-36. DOI:10.1016/j.cmet.2016.04.003

Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D’Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE (2016) 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.  Dis Model Mech. 9:401-12. doi: 10.1242/dmm.023903

Arch JR (2013) Horizons in the pharmacotherapy of obesity, Curr Obes Rep, 4:451-9 doi:10.1007/s13679-015-0177-4

Arch, JR and Trayhurn, P (2013) Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification. Front Physiol 8;4: 64 doi:10.3389/fphys.2013.00064

Ngala RA, O’Dowd JF, Stocker CJ,  Cawthorne MA, Arch JRS (2013) β₂-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling. Naunyn-Schmiedeberg’s Archives of Pharmacology 386(9):761-73 doi:10.1007/s00210-013-0860-5

Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV Jr, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E (2011) A guide to analysis of mouse energy metabolism. Nature Methods 9: 57-63 doi:10.1038/nmeth.1806 409 citations.

Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, Smith SA, Beeley LJ, Godden RJ, Herrity N, Skehel M, Changani KK, Hockings PD, Reid DG, Squires SM, Hatcher J, Trail B, Latcham J, Rastan S, Harper AJ, Cadenas S, Buckingham JA, Brand MD, Abuin A (2000) Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406, (6794), 415-8 doi:10.1038/35019082 648 citations.

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors – a family of hypothalamic neuropeptides and G-protein coupled receptors that regulate feeding behaviour. Cell 92, (4), 573-585 doi:10.1016/S0092-8674(00)80949-6 4969 citations.

Arch JR, Ainsworth AT, Cawthorne MA, Piercy V, Sennitt MV, Thody VE, Wilson C, Wilson S (1984) Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309, 163-165 doi:10.1038/309163a0 847 citations